Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | AADAC | P22760 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2702598 | 1.00 | KDM4E (0.42) | KDM4ERECQLALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL550053 | 1.00 | KDM4E (0.42) | KDM4ERECQLALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL550052 | 1.00 | KDM4E (0.42) | KDM4ERECQLALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL2702601 | 1.00 | KDM4E (0.42) | KDM4ERECQLALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL551713 | 1.00 | KDM4E (0.42) | KDM4ERECQLALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL551111 | 0.91 | MAPT (0.40) | KDM4EALDH1A1CYP2C9TSHRMAPK1 | |
| SCHEMBL550880 | 0.91 | MAPT (0.40) | KDM4EALDH1A1CYP2C9TSHRMAPK1 | |
| SCHEMBL2699038 | 0.91 | MAPT (0.40) | KDM4EALDH1A1CYP2C9TSHRMAPK1 | |
| SCHEMBL551112 | 0.91 | MAPT (0.40) | KDM4EALDH1A1CYP2C9TSHRMAPK1 | |
| SCHEMBL550881 | 0.91 | MAPT (0.40) | KDM4EALDH1A1CYP2C9TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |