Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL633008 | 0.81 | USP30 (0.42) | KDM4EPOLBGPR119USP30ALOX5AP | |
| SCHEMBL5775824 | 0.75 | POLB (0.47) | POLBGPR119MAP4K4GRM5 | |
| SCHEMBL5636825 | 0.73 | JAK1 (0.40) | MAP4K4 | |
| SCHEMBL5509551 | 0.71 | ALDH1A1 (0.42) | POLBGPR119ALOX5APFEN1 | |
| SCHEMBL5747116 | 0.71 | POLB (0.41) | KDM4EPOLBGPR119MAP4K4GRM5 | |
| SCHEMBL5748387 | 0.71 | POLB (0.41) | POLBGPR119MAP4K4USP30GRM5 | |
| SCHEMBL5748603 | 0.71 | POLB (0.41) | KDM4EPOLBGPR119MAP4K4GRM5 | |
| SCHEMBL5517583 | 0.70 | KCNH2 (0.44) | KDM4EPOLBMAP4K4MEN1KMT2A | |
| SCHEMBL5636179 | 0.70 | KDM4D (0.33) | KDM4EMAP4K4 | |
| SCHEMBL5260297 | 0.70 | KDM4D (0.33) | KDM4EMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | disclosed |