Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | POLA1 | P09884 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | PEPD | P12955 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5512726 | 1.00 | HDAC8 (0.38) | HDAC8IMPDH2SPHK1PTPN1MAPK1 | |
| SCHEMBL2380326 | 0.87 | IMPDH2 (0.39) | HDAC8IMPDH2SPHK1PTPN1MAPK1 | |
| SCHEMBL2380328 | 0.87 | IMPDH2 (0.39) | HDAC8IMPDH2SPHK1PTPN1MAPK1 | |
| SCHEMBL16774639 | 0.85 | IMPDH2 (0.39) | HDAC8IMPDH2PTPN1MAPK1NR1H2 | |
| SCHEMBL16774503 | 0.85 | IMPDH2 (0.39) | HDAC8IMPDH2PTPN1MAPK1NR1H2 | |
| SCHEMBL16635559 | 0.85 | IMPDH2 (0.39) | HDAC8IMPDH2PTPN1MAPK1NR1H2 | |
| SCHEMBL16647818 | 0.85 | IMPDH2 (0.39) | HDAC8IMPDH2PTPN1MAPK1NR1H2 | |
| SCHEMBL5519647 | 0.84 | HDAC8 (0.37) | HDAC8IMPDH2SPHK1PTPN1MAPK1 | |
| SCHEMBL16774547 | 0.84 | HDAC8 (0.40) | HDAC8IMPDH2PTPN1MAPK1NR1H2 | |
| SCHEMBL16774546 | 0.84 | HDAC8 (0.40) | HDAC8IMPDH2PTPN1MAPK1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199105-B2 | Lincomycin derivatives possessing antibacterial activity | VICURON PHARMACEUTICALS, INC. (US) | 2007-04-03 | — | — | US | disclosed |
| US-7164011-B2 | Lincomycin derivatives possessing antibacterial activity | VICURON PHARMACEUTICALS, INC. (US) | 2007-01-16 | — | — | US | disclosed |