SCHEMBL5520116

SCHEMBL5520116

O=Cc1cc2c(cc1F)NC(=O)CS2

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.45
MAOB P27338 6/20 0.45
EPHX2 P34913 1/20 0.45
HTT P42858 2/20 0.44
ALDH1A1 P00352 2/20 0.40
LMNA P02545 1/20 0.40
KMT2A Q03164 1/20 0.39
CYP11B1 P15538 1/20 0.37
CYP11B2 P19099 1/20 0.37
PDE3B Q13370 1/20 0.37
PDE3A Q14432 1/20 0.37
KIF11 P52732 1/20 0.36
TRPV1 Q8NER1 1/20 0.36
HPGD P15428 1/20 0.35
CA2 P00918 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3071633 0.94 MAOA (0.45) MAOAMAOBEPHX2HTTALDH1A1
SCHEMBL621997 0.77 MAOA (0.45) MAOAMAOBEPHX2HTTALDH1A1
SCHEMBL7451837 0.73 MAOA (0.47) MAOAMAOBEPHX2HTTALDH1A1
SCHEMBL30954132 0.73 MAOA (0.47) MAOAMAOBEPHX2HTTALDH1A1
SCHEMBL1223787 0.73 MAOA (0.47) MAOAMAOBEPHX2HTTALDH1A1
SCHEMBL14341235 0.73 EPHX2 (0.56) MAOAMAOBEPHX2HTTALDH1A1
SCHEMBL622422 0.72 HTT (0.56) MAOAMAOBEPHX2HTTALDH1A1
SCHEMBL10509516 0.71 HTT (0.59) MAOAMAOBEPHX2HTTALDH1A1
SCHEMBL3069824 0.71 MAOB (0.49) MAOAMAOBEPHX2HTTALDH1A1
SCHEMBL3248456 0.70 MAOB (0.44) MAOAMAOBEPHX2HTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1799676-A2 NEW BICYCLIC ANTIBIOTICS Actelion Pharmaceuticals Ltd. (CH) 2007-06-27 EP disclosed
WO-2006032466-A2 NEW BICYCLIC ANTIBIOTICS ACTELION PHARMACEUTICALS LTD (CH) 2006-03-30 WO disclosed