Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 12/20 | 0.41 |
| ▸ | HTR2A | P28223 | 8/20 | 0.41 |
| ▸ | HTR1A | P08908 | 6/20 | 0.41 |
| ▸ | DRD3 | P35462 | 6/20 | 0.40 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2782993 | 0.92 | DRD2 (0.44) | ALDH1A1DRD2HTR2AHTR1ADRD3 | |
| SCHEMBL2782426 | 0.91 | GAA (0.41) | KDM4EALDH1A1DRD2DRD3ABCB1 | |
| SCHEMBL5508720 | 0.90 | DRD2 (0.45) | KDM4EALDH1A1DRD2HTR2AHTR1A | |
| SCHEMBL2784018 | 0.81 | DRD2 (0.48) | ALDH1A1DRD2HTR2AHTR1ADRD3 | |
| SCHEMBL2780681 | 0.81 | ABCB1 (0.50) | ALDH1A1DRD2HTR2AHTR1ADRD3 | |
| SCHEMBL2783579 | 0.80 | DRD2 (0.51) | DRD2HTR2AHTR1ADRD3DRD4 | |
| SCHEMBL2783650 | 0.80 | DRD2 (0.48) | ALDH1A1DRD2HTR2AHTR1ADRD3 | |
| SCHEMBL5505222 | 0.80 | DRD2 (0.48) | KDM4EALDH1A1DRD2HTR2AHTR1A | |
| SCHEMBL2785169 | 0.79 | TTR (0.41) | KDM4EALDH1A1DRD2HTR1ADRD3 | |
| SCHEMBL2784881 | 0.78 | ABCB1 (0.49) | KDM4EALDH1A1DRD2DRD3ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | claimed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | claimed |