Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.46 |
| ▸ | DRD2 | P14416 | 7/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | RB1 | P06400 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895948 | 1.00 | HTR1A (0.46) | HTR1ASLC6A4DRD2HTR2AHTR2B | |
| SCHEMBL4898323 | 1.00 | HTR1A (0.46) | HTR1ASLC6A4DRD2HTR2AHTR2B | |
| SCHEMBL4905470 | 1.00 | HTR1A (0.46) | HTR1ASLC6A4DRD2HTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL4903764 | 0.99 | HTR1A (0.46) | HTR1ASLC6A4DRD2HTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL4903849 | 0.99 | HTR1A (0.46) | HTR1ASLC6A4DRD2HTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL4904201 | 0.99 | HTR1A (0.46) | HTR1ASLC6A4DRD2HTR2AHTR2B | |
| SCHEMBL4900695 | 0.89 | RB1 (0.48) | HTR1ASLC6A4DRD2HTR2AHTR2B | |
| SCHEMBL4904593 | 0.89 | RB1 (0.48) | HTR1ASLC6A4DRD2HTR2AHTR2B | |
| SCHEMBL4899564 | 0.89 | RB1 (0.48) | HTR1ASLC6A4DRD2HTR2AHTR2B | |
| SCHEMBL4904197 | 0.89 | SLC6A4 (0.60) | HTR1ASLC6A4DRD2HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856126-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006089053-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2006-08-24 | — | — | WO | claimed |
| EP-1856126-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006089053-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |