Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.76 |
| ▸ | CA12 | O43570 | 3/20 | 0.74 |
| ▸ | CA1 | P00915 | 3/20 | 0.74 |
| ▸ | CA2 | P00918 | 3/20 | 0.74 |
| ▸ | CA9 | Q16790 | 3/20 | 0.74 |
| ▸ | AR | P10275 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 9/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | CASP1 | P29466 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | GAPDH | P04406 | 1/20 | 0.59 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.59 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5522476 | 1.00 | CHRNA7 (0.76) | CHRNA7CA12CA1CA2CA9 | |
| SCHEMBL5516230 | 1.00 | CHRNA7 (0.76) | CHRNA7CA12CA1CA2CA9 | |
| SCHEMBL5524785 | 0.89 | CA12 (0.80) | CHRNA7CA12CA1CA2CA9 | |
| SCHEMBL17464435 | 0.89 | CA12 (0.87) | CHRNA7CA12CA1CA2CA9 | |
| SCHEMBL17458837 | 0.89 | CA12 (0.87) | CHRNA7CA12CA1CA2CA9 | |
| SCHEMBL17458859 | 0.87 | CA12 (0.77) | CHRNA7CA12CA1CA2CA9 | |
| SCHEMBL17464562 | 0.87 | CA12 (0.77) | CHRNA7CA12CA1CA2CA9 | |
| SCHEMBL17458755 | 0.87 | CA12 (0.73) | CHRNA7CA12CA1CA2CA9 | |
| SCHEMBL17464439 | 0.87 | CA12 (0.73) | CHRNA7CA12CA1CA2CA9 | |
| SCHEMBL1458619 | 0.86 | CHRNA7 (1.00) | CHRNA7CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070179172-A1 | Positive modulators of nicotinic acetylcholine receptors | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | US | claimed |
| EP-1631288-A1 | POSITIVE MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | AstraZeneca AB (SE) | 2006-03-08 | — | — | EP | claimed |
| WO-2004098600-A1 | POSITIVE MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | ASTRAZENECA AB (SE) | 2004-11-18 | — | — | WO | claimed |
| US-20070179172-A1 | Positive modulators of nicotinic acetylcholine receptors | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | US | disclosed |
| US-20070179172-A1 | Positive modulators of nicotinic acetylcholine receptors | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | US | disclosed |
| US-20070179172-A1 | Positive modulators of nicotinic acetylcholine receptors | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | US | disclosed |
| EP-1631288-A1 | POSITIVE MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | AstraZeneca AB (SE) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004098600-A1 | POSITIVE MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | ASTRAZENECA AB (SE) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179172-A1 | Positive modulators of nicotinic acetylcholine receptors | CHRNA1, CHRNA2, CHRM1 | CHRNA7 10/4885CA12 2730/4885CA1 1912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.