SCHEMBL5523660

SCHEMBL5523660

N#C[C@@H]1C[C@H](F)CN1C(=O)CNC1CC[C@H](Cn2cncn2)C1

nearest known ligand 0.63

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 20/20 0.63
DPP8 Q6V1X1 4/20 0.46
DPP7 Q9UHL4 4/20 0.46
PREP P48147 2/20 0.46
DPP9 Q86TI2 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18434957 1.00 DPP4 (0.63) DPP4DPP8DPP7PREPDPP9
SCHEMBL7738031 1.00 DPP4 (0.63) DPP4DPP8DPP7PREPDPP9
SCHEMBL12872570 1.00 DPP4 (0.63) DPP4DPP8DPP7PREPDPP9
SCHEMBL15043900 1.00 DPP4 (0.63) DPP4DPP8DPP7PREPDPP9
SCHEMBL1593467 1.00 DPP4 (0.63) DPP4DPP8DPP7PREPDPP9
SCHEMBL20162037 1.00 DPP4 (0.63) DPP4DPP8DPP7PREPDPP9
SCHEMBL1154515 1.00 DPP4 (0.63) DPP4DPP8DPP7PREPDPP9
SCHEMBL1154638 1.00 DPP4 (0.63) DPP4DPP8DPP7PREPDPP9
SCHEMBL20888696 1.00 DPP4 (0.63) DPP4DPP8DPP7PREPDPP9
SCHEMBL12872828 1.00 DPP4 (0.63) DPP4DPP8DPP7PREPDPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7205323-B2 Dipeptidyl peptidase IV inhibitors pharmaceutical compositions containing them, and process for their preparation GLENMARK PHARMACEUTICALS S.A. (CH) 2007-04-17 US claimed
EP-3598974-A1 TREATMENT FOR DIABETES IN PATIENTS INAPPROPRIATE FOR METFORMIN THERAPY Boehringer Ingelheim International GmbH (DE) 2020-01-29 EP disclosed
EP-3150204-A2 TREATMENT FOR DIABETES IN PATIENTS WITH INSUFFICIENT GLYCEMIC CONTROL DESPITE THERAPY WITH AN ORAL OR NON-ORAL ANTIDIABETIC DRUG Boehringer Ingelheim International GmbH (DE) 2017-04-05 EP disclosed
EP-3124041-A1 DIABETES THERAPY Boehringer Ingelheim International GmbH (DE) 2017-02-01 EP disclosed
EP-1799639-B1 NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESS FOR THEIR PREPARATION GLENMARK PHARMACEUTICALS SA (CH) 2013-09-04 EP disclosed