Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 14/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.47 |
| ▸ | EDNRB | P24530 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5536632 | 0.98 | EDNRA (0.47) | EDNRAAGTR1EDNRBCCNT1CDK9 | |
| SCHEMBL5524241 | 0.96 | EDNRA (0.47) | EDNRAAGTR1EDNRBCCNT1CDK9 | |
| SCHEMBL5530717 | 0.95 | EDNRA (0.45) | EDNRAAGTR1EDNRBCCNT1CDK9 | |
| SCHEMBL5529007 | 0.94 | EDNRA (0.54) | EDNRAAGTR1EDNRBCCNT1CDK9 | |
| SCHEMBL5534119 | 0.94 | EDNRA (0.48) | EDNRAAGTR1EDNRB | |
| SCHEMBL4767095 | 0.93 | EDNRA (0.47) | EDNRAAGTR1EDNRB | |
| SCHEMBL5533224 | 0.92 | EDNRA (0.48) | EDNRAAGTR1EDNRB | |
| SCHEMBL4769515 | 0.92 | EDNRA (0.46) | EDNRAAGTR1EDNRBCCNT1CDK9 | |
| SCHEMBL5528411 | 0.90 | EDNRA (0.52) | EDNRAAGTR1EDNRBCCNT1CDK9 | |
| SCHEMBL6539733 | 0.90 | EDNRA (0.48) | EDNRAAGTR1EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1741713-A2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | Bristol-Myers Squibb Company (US) | 2007-01-10 | — | — | EP | claimed |
| US-20040127515-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | PHARMACOPEIA, LLC | 2004-07-01 | — | — | US | claimed |
| US-20040106833-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | PHARMACOPEIA, LLC | 2004-06-03 | — | — | US | claimed |
| US-20020143024-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | PHARMACOPEIA, LLC | 2002-10-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127515-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | EDNRB, AGTR2, EDNRA | EDNRA 3/4885AGTR1 4/4885EDNRB 1/4885 |
| US-20020143024-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | EDNRB, AGTR2, EDNRA | EDNRA 3/4885AGTR1 4/4885EDNRB 1/4885 |
| US-20040106833-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | EDNRB, AGTR2, EDNRA | EDNRA 3/4885AGTR1 4/4885EDNRB 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.