Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL17500037 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL9723996 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL896564 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21935 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL3216454 | 0.94 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5421322 | 0.94 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1856156 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL524765 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL3958237 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL29401923 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060900-A1 | Ostomy Device with Deodorizing Efficacy | NATIONAL RESEARCH LABORATORIES, LTD. (US) | 2007-03-15 | — | — | US | disclosed |
| US-20060165610-A1 | Composition for Treating and Preventing Periodontal Disease and Method of Use | NATIONAL RESEARCH LABORATORIES, LTD. (US) | 2006-07-27 | — | — | US | disclosed |
| US-20060165611-A1 | Composition for Treating and Preventing Periodontal Disease and Method of Use | NATIONAL RESEARCH LABORATORIES, LTD. (US) | 2006-07-27 | — | — | US | disclosed |
| US-20060089407-A1 | Methods for Making and Using Synergistic Multifunctional Compositions | NATIONAL RESEARCH LABORATORIES, LTD. (US) | 2006-04-27 | — | — | US | disclosed |
| US-20060088477-A1 | Compositions and Methods of Dispensing Palliative or Therapeutic Agents | NATIONAL RESEARCH LABORATORIES, LTD. (US) | 2006-04-27 | — | — | US | disclosed |
| US-4680309-A | DIALKALI METAL HEAVY CHELATE OF A HYDROXY POLYCARBOXYLIC ACID | NATIONAL RESEARCH LABORATORIES (US) | 1987-07-14 | — | — | US | disclosed |