Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507244 | 0.80 | PTGS2 (0.34) | PTGS2PTGS1 | |
| SCHEMBL5507246 | 0.80 | PTGS2 (0.34) | PTGS2PTGS1 | |
| SCHEMBL5509364 | 0.80 | PTPN1 (0.43) | — | |
| SCHEMBL5503559 | 0.78 | PTPN1 (0.41) | PTGS2PTGS1 | |
| SCHEMBL5504720 | 0.77 | PTPN1 (0.38) | PTGS2PTGS1 | |
| SCHEMBL5988072 | 0.77 | PTPN5 (0.37) | PTGS2PTGS1 | |
| SCHEMBL5503199 | 0.76 | PTPN1 (0.34) | — | |
| SCHEMBL5503895 | 0.76 | PTPN1 (0.37) | FLT1FLT4KDR | |
| SCHEMBL5500769 | 0.75 | PTPN1 (0.37) | PTGS2 | |
| SCHEMBL5503231 | 0.73 | PTPN1 (0.36) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786421-A2 | OXYGEN/NITROGEN HETEROCYCLE INHIBITORS OF TYROSINE PHOSPHATASES | Cengent Therapeutics, Inc. (US) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006017124-A2 | OXYGEN/NITROGEN HETEROCYCLE INHIBITORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-02-16 | — | — | WO | disclosed |