Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 2/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TOP2A | P11388 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5981802 | 0.94 | MEN1 (0.50) | MEN1PKMKMT2APOLBRAD52 | |
| SCHEMBL2052464 | 0.79 | MEN1 (0.57) | MEN1PKMKMT2APOLBRAD52 | |
| SCHEMBL5508099 | 0.77 | MEN1 (0.47) | MEN1PKMKMT2APOLBRAD52 | |
| SCHEMBL5500673 | 0.76 | KMT2A (0.72) | MEN1PKMKMT2APOLBRAD52 | |
| SCHEMBL5502811 | 0.74 | MEN1 (0.47) | MEN1PKMKMT2APOLBRAD52 | |
| SCHEMBL5506961 | 0.72 | MEN1 (0.49) | MEN1PKMKMT2APOLBRAD52 | |
| SCHEMBL18998176 | 0.70 | ALDH1A1 (0.48) | MEN1PKMKMT2AHPGDMAPT | |
| SCHEMBL4788245 | 0.69 | CSF1R (0.56) | MAPTKDM4EALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL7540120 | 0.68 | PTPN1 (0.45) | MEN1PKMKMT2AHPGDMAPT | |
| SCHEMBL1959406 | 0.67 | POLB (0.46) | MEN1PKMKMT2APOLBRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753724-A1 | HETEROCYCLIC DERIVATIVES FOR TREATMENT OF HYPERLIPIDEMIA AND RELATED DISEASES | AVANIR PHARMACEUTICALS (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005123686-A1 | HETEROCYCLIC DERIVATIVES FOR TREATMENT OF HYPERLIPIDEMIA AND RELATED DISEASES | AVANIR PHARMACEUTICALS (US) | 2005-12-29 | — | — | WO | disclosed |