Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4761629 | 0.80 | PARP1 (1.00) | PARP1HPGDLMNAALDH1A1KDM4E | |
| SCHEMBL9836935 | 0.79 | PARP1 (0.97) | PARP1HPGDLMNAALDH1A1KDM4E | |
| SCHEMBL5522439 | 0.77 | PARP1 (1.00) | PARP1HPGDALDH1A1KDM4EMAPT | |
| SCHEMBL5532024 | 0.75 | PARP1 (0.65) | PARP1HPGDSMN1; SMN2ALOX15 | |
| SCHEMBL5523619 | 0.75 | PARP1 (0.56) | PARP1ALDH1A1GAA | |
| SCHEMBL5520379 | 0.75 | PARP1 (0.56) | PARP1 | |
| SCHEMBL4724551 | 0.74 | PARP1 (0.63) | PARP1HPGDSMN1; SMN2ALOX15 | |
| SCHEMBL5520388 | 0.74 | PARP1 (0.55) | PARP1HPGDALDH1A1KDM4E | |
| SCHEMBL5534195 | 0.73 | PARP1 (0.62) | PARP1HPGDALDH1A1KMT2AKDM4E | |
| SCHEMBL5522637 | 0.73 | PARP1 (0.62) | PARP1SMN1; SMN2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249597-A1 | PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS | ABBVIE INC. | 2007-10-25 | — | — | US | claimed |
| EP-2578587-B1 | PYRAZOLE DERIVATIVES | HANDE STARLAKE BIOSCIENCE CO LTD (CN) | 2016-09-07 | — | — | EP | disclosed |
| EP-2468748-B1 | Pyrazoloquinolones are potent parp inhibitors | ABBVIE INC (US) | 2016-05-25 | — | — | EP | disclosed |
| US-9249172-B2 | Pyrazole derivatives | HANDE PHARMA LIMITED (CN) | 2016-02-02 | — | — | US | disclosed |
| US-20140213610-A1 | PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS | ABBVIE INC. (US) | 2014-07-31 | — | — | US | disclosed |
| EP-1989204-B1 | PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS | ABBVIE INC (US) | 2014-05-21 | — | — | EP | disclosed |
| US-8546368-B2 | Pyrazoloquinolones are potent PARP inhibitors | ABBVIE INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20130142757-A1 | PYRAZOLE DERIVATIVES | HANDE STARLAKE BIOSCIENCE CO., LTD. (CN) | 2013-06-06 | — | — | US | disclosed |
| EP-2578587-A1 | PYRAZOLE DERIVATIVES | Hande Starlake Bioscience Co., Ltd. (CN) | 2013-04-10 | — | — | EP | disclosed |
| EP-2468748-A1 | Pyrazoloquinolones are potent parp inhibitors | Abbott Laboratories (US) | 2012-06-27 | — | — | EP | disclosed |
| US-20070249597-A1 | PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS | ABBVIE INC. | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213610-A1 | PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP3 | PARP1 1/4885NPSR1 4449/4885PPARG 1505/4885 |
| US-20070249597-A1 | PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP3 | PARP1 1/4885NPSR1 4449/4885PPARG 1505/4885 |
| US-20130142757-A1 | PYRAZOLE DERIVATIVES | CBR3, CBR1, CYP2E1 | PARP1 791/4885NPSR1 787/4885PPARG 228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.