Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.71 |
| ▸ | PDE4A | P27815 | 18/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5525607 | 1.00 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL5525610 | 1.00 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL6546065 | 0.89 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL6546061 | 0.89 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL28381093 | 0.85 | PDE4B (0.92) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL16730939 | 0.84 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| Cilomilast SCHEMBL13777301 | 0.83 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL27515 | 0.83 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL27516 | 0.83 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL26372 | 0.83 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154758-A4 | CONTROLLED RELEASE FORMULATION FOR TREATING COPD | SMITHKLINE BEECHAM CORP (US) | 2007-09-05 | — | — | EP | disclosed |
| EP-1420011-A1 | Compounds usefulfor treating allergic and inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 2004-05-19 | — | — | EP | disclosed |
| US-6713509-B1 | HIGH MOLECULAR WEIGHT CROSSLINKED ACRYLIC ACID POLYMER, DIBASIC CALCIUM PHOSPHATE AND PHOSPHODIESTERASE ISOZYME DENOMINATED 4 INHIBITOR; CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) | SMITHKLINE BEECHAM CORPORATION | 2004-03-30 | — | — | US | disclosed |
| EP-1380571-A1 | Compounds useful for treating allergic and inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-14 | — | — | EP | disclosed |
| US-20030211152-A1 | Controlled release formulation for treating COPD | SMITHKLINE BEECHAM CORPORATION | 2003-11-13 | — | — | US | disclosed |
| EP-0919544-B1 | Compounds useful for treating allergic and inflammatory diseases | SMITHKLINE BEECHAM CORP (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-1154758-A1 | CONTROLLED RELEASE FORMULATION FOR TREATING COPD | SmithKline Beecham Corporation (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-0633776-B1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC AND INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORP (US) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000050011-A1 | CONTROLLED RELEASE FORMULATION FOR TREATING COPD | SMITHKLINE BEECHAM CORPORATION (US) | 2000-08-31 | — | — | WO | disclosed |
| EP-0919544-A1 | Compounds useful for treating allergic and inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1999-06-02 | — | — | EP | disclosed |
| US-5643946-A | Compounds useful for treating allergic and inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |
| US-5614540-A | Compounds useful for treating allergic and inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-03-25 | — | — | US | disclosed |
| US-5602157-A | Compounds useful for treating allergic and inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-11 | — | — | US | disclosed |
| US-5552438-A | Compounds useful for treating allergic and inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1996-09-03 | — | — | US | disclosed |