⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28331698 | 0.98 | LMNA (0.42) | — | |
| SCHEMBL20553423 | 0.98 | LMNA (0.42) | — | |
| SCHEMBL28266398 | 0.98 | LMNA (0.42) | — | |
| SCHEMBL29098538 | 0.98 | LMNA (0.42) | — | |
| SCHEMBL28331697 | 0.98 | LMNA (0.42) | — | |
| SCHEMBL2678528 | 0.92 | — | — | |
| Carbamic Acid SCHEMBL2823803 | 0.88 | LMNA (0.47) | — | |
| SCHEMBL2746597 | 0.87 | TSHR (0.52) | — | |
| SCHEMBL2746089 | 0.84 | TSHR (0.50) | — | |
| SCHEMBL2059697 | 0.84 | TSHR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113402523-B | Targeted mast cell MrgX2 small-molecule fluorescent probe and preparation method and application thereof | 西安交通大学 | 2022-07-12 | — | — | CN | claimed |
| CN-113402523-A | Targeted mast cell MrgX2 small-molecule fluorescent probe and preparation method and application thereof | 西安交通大学 | 2021-09-17 | — | — | CN | claimed |
| EP-4731309-A1 | KRAS PROTEOLYSIS TARGETING CHIMERAS | Paq Therapeutics Inc. (US) | 2026-04-29 | — | — | EP | disclosed |
| US-12404285-B2 | KRAS G12D proteolysis targeting chimeras | PAQ Therapeutics Inc. (US) | 2025-09-02 | — | — | US | disclosed |
| US-20250051364-A1 | KRAS G12D Proteolysis Targeting Chimeras | PAQ Therapeutics Inc. (US) | 2025-02-13 | — | — | US | disclosed |
| WO-2024263586-A1 | KRAS PROTEOLYSIS TARGETING CHIMERAS | PAQ Therapeutics Inc. (US) | 2024-12-26 | — | — | WO | disclosed |
| US-20240247000-A1 | KRAS G12D Proteolysis Targeting Chimeras | PAQ Therapeutics Inc. (US) | 2024-07-25 | — | — | US | disclosed |
| EP-4398911-A2 | INK4 TUMOR SUPPRESSOR PROTEINS MEDIATE RESISTANCE TO CDK4/6 KINASE INHIBITORS | Memorial Sloan Kettering Cancer Center (US) | 2024-07-17 | — | — | EP | disclosed |
| EP-4392420-A1 | HPK1 DEGRADERS, COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | BIOFRONT LTD (KY) | 2024-07-03 | — | — | EP | disclosed |
| CN-117362239-B | Luminol etherified derivative and preparation method and application thereof | 广州中医药大学(广州中医药研究院) | 2024-06-07 | — | — | CN | disclosed |
| CN-112079866-B | ALK protein regulator and anti-tumor application thereof | 上海科技大学 | 2024-05-31 | — | — | CN | disclosed |
| CN-110770243-A | Rapamycin analogs as MTOR inhibitors | 锐新医药公司 | 2020-02-07 | — | — | CN | disclosed |
| CN-110615779-A | Process for preparing lenalidomide derivatives | 上海科技大学 | 2019-12-27 | — | — | CN | disclosed |
| CN-110357889-A | Protein degradation target compound, its antitumor application thereof, wherein mesosome and intermediate application | 上海科技大学 | 2019-10-22 | — | — | CN | disclosed |
| CN-109912655-A | Alk protein degradation agent and its antitumor application thereof | 上海科技大学 | 2019-06-21 | — | — | CN | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
| CN-1374863-A | Bicyclic antagonists selective for the alpha beta integrin | WHAE S INC (US) | 2002-10-16 | — | — | CN | disclosed |
| US-5691319-A | ANTICARCINOGENIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-11-25 | — | — | US | disclosed |
| EP-0536936-B1 | Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use | SANKYO CO (JP) | 1996-08-14 | — | — | EP | disclosed |
| EP-0536936-A1 | Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use | Sankyo Company Limited (JP) | 1993-04-14 | — | — | EP | disclosed |