Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.54 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5521792 | 0.82 | HCAR2 (0.51) | HCAR2HCAR3CYP1A2DRD2SIGMAR1 | |
| SCHEMBL5522028 | 0.80 | HCAR2 (0.57) | HCAR2HCAR3CYP1A2BACE1ALDH1A1 | |
| SCHEMBL11414250 | 0.77 | HCAR2 (0.53) | HCAR2HCAR3CYP1A2DRD2SIGMAR1 | |
| SCHEMBL5519567 | 0.74 | HCAR2 (0.35) | HCAR2HCAR3CYP1A2DRD2SIGMAR1 | |
| SCHEMBL5519630 | 0.73 | HCAR2 (0.53) | HCAR2HCAR3CYP1A2DRD2SIGMAR1 | |
| SCHEMBL5531379 | 0.71 | HCAR2 (0.55) | HCAR2HCAR3CYP1A2BACE1 | |
| SCHEMBL3101007 | 0.70 | HCAR2 (1.00) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL5521501 | 0.67 | HCAR2 (0.56) | HCAR2HCAR3MEN1KMT2APGR | |
| SCHEMBL3100362 | 0.67 | HCAR2 (0.43) | HCAR2HCAR3CYP1A2DRD2SIGMAR1 | |
| SCHEMBL3094399 | 0.67 | HCAR2 (0.53) | HCAR2HCAR3CYP1A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070093545-A1 | 4-Oxo-4,5-dihydro-furan-2-carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof | ARENA PHARMACEUTICALS, INC. (US) | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093545-A1 | 4-Oxo-4,5-dihydro-furan-2-carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof | ABAT, G6PD, GLS2 | HCAR2 229/4885HCAR3 373/4885CYP1A2 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.