Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.35 |
| ▸ | CDK2 | P24941 | 10/20 | 0.35 |
| ▸ | CDK7 | P50613 | 9/20 | 0.35 |
| ▸ | CCNH | P51946 | 9/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 9/20 | 0.35 |
| ▸ | CCNK | O75909 | 7/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.35 |
| ▸ | MAP3K6 | O95382 | 2/20 | 0.35 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5534111 | 0.73 | MAP3K5 (0.39) | MAP3K5ROCK2CCNA2CDK2CDK7 | |
| SCHEMBL31143762 | 0.71 | MAP3K5 (0.54) | MAP3K5FDPSROCK2CCNA2CDK2 | |
| SCHEMBL8986816 | 0.71 | MAP3K5 (0.54) | MAP3K5FDPSROCK2CCNA2CDK2 | |
| SCHEMBL6307534 | 0.70 | NPC1 (0.58) | MAP3K5FDPSKDM4EALDH1A1 | |
| SCHEMBL31060745 | 0.70 | NPC1 (0.58) | MAP3K5FDPSKDM4EALDH1A1 | |
| SCHEMBL1483456 | 0.70 | MAP3K5 (0.68) | MAP3K5FDPSMAP3K7MAP3K6KDM4E | |
| SCHEMBL28347289 | 0.67 | MAP3K5 (0.50) | MAP3K5FDPSCCNA2CDK2CDK7 | |
| SCHEMBL28219941 | 0.67 | MAP3K5 (0.50) | MAP3K5FDPSROCK2CCNA2CDK2 | |
| SCHEMBL28357831 | 0.66 | CCNK (0.53) | MAP3K5FDPSCCNA2CDK2CDK7 | |
| SCHEMBL6524322 | 0.66 | CCNA2 (0.57) | MAP3K5CCNA2CDK2CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | MAP3K5 1342/4885FDPS 4602/4885ROCK2 1013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.