Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | NOTCH1 | P46531 | 4/20 | 0.42 |
| ▸ | NOTCH3 | Q9UM47 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | RBPJ | Q06330 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.41 |
| ▸ | CCKBR | P32239 | 3/20 | 0.41 |
| ▸ | CCKAR | P32238 | 2/20 | 0.41 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.41 |
| ▸ | OXTR | P30559 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4193934 | 1.00 | SCN9A (0.43) | SCN9ANOTCH1NOTCH3KCNH2RBPJ | |
| SCHEMBL4193932 | 1.00 | SCN9A (0.43) | SCN9ANOTCH1NOTCH3KCNH2RBPJ | |
| SCHEMBL4177786 | 0.94 | SCN9A (0.45) | SCN9ANOTCH1NOTCH3KCNH2PSEN1 | |
| SCHEMBL4177788 | 0.94 | SCN9A (0.45) | SCN9ANOTCH1NOTCH3KCNH2PSEN1 | |
| SCHEMBL4196035 | 0.93 | NOTCH1 (0.47) | NOTCH1NOTCH3KCNH2RBPJPSEN1 | |
| SCHEMBL4196037 | 0.93 | NOTCH1 (0.47) | NOTCH1NOTCH3KCNH2RBPJPSEN1 | |
| SCHEMBL4180338 | 0.89 | NOTCH1 (0.42) | NOTCH1NOTCH3KCNH2RBPJPSEN1 | |
| SCHEMBL4188779 | 0.89 | NOTCH1 (0.44) | NOTCH1NOTCH3KCNH2RBPJPSEN1 | |
| SCHEMBL4188776 | 0.89 | NOTCH1 (0.44) | NOTCH1NOTCH3KCNH2RBPJPSEN1 | |
| SCHEMBL4178279 | 0.89 | CCKBR (0.43) | SCN9ACCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027132-A1 | Hydroxyalkanoylaminolactams and related structures as inhibitors of Alphabeta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-02-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027132-A1 | Hydroxyalkanoylaminolactams and related structures as inhibitors of Alphabeta protein production | APP, BACE1, APH1A | SCN9A 44/4885NOTCH1 625/4885NOTCH3 1667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.