⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18124555 | 0.72 | — | — | |
| SCHEMBL1565515 | 0.72 | — | — | |
| SCHEMBL19337928 | 0.72 | — | — | |
| SCHEMBL716179 | 0.70 | — | — | |
| SCHEMBL3521660 | 0.70 | — | — | |
| SCHEMBL1565514 | 0.70 | — | — | |
| SCHEMBL822876 | 0.70 | — | — | |
| SCHEMBL12585236 | 0.70 | — | — | |
| SCHEMBL17645066 | 0.70 | — | — | |
| SCHEMBL198306 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025137507-A1 | SOS1 INHIBITORS AND USES THEREOF | REGOR PHARMACEUTICALS, INC. (US) | 2025-06-26 | — | — | WO | disclosed |
| WO-2013010453-A1 | CHEMOKING RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2013-01-24 | — | — | WO | disclosed |
| CN-100467468-C | Triaza-spiropiperidine derivatives for use as GLYT-1 inhibitors in the treatment of neurological and neuropsychiatric disorders | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | CN | disclosed |
| US-20070276142-A1 | Catalytic Asymmetric Synthesis of Optically Active Alpha-Halo-Carbonyl Compounds | CHEMINOVA A/S (DK) | 2007-11-29 | — | — | US | disclosed |
| EP-1678177-B1 | TRIAZA-SPIROPIPERIDINE DERIVATIVES FOR USE AS GLYT-1 INHIBITORS IN THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | HOFFMANN LA ROCHE (CH) | 2007-11-28 | — | — | EP | disclosed |
| US-7189850-B2 | E.g., 1-phenyl-8-(2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one; activation of N-methylaspartic acid receptors via Glycine (Gly t-1) inhibition; psychoses; analgesics; neurodegenerative and psychological disorders; schizophrenia; cognition activators; antidepressants; Alzheimer's disease | HOFFMANN-LA ROCHE INC. (US) | 2007-03-13 | — | — | US | disclosed |
| CN-1922121-A | Catalytic asymmetric synthesis of optically active alpha-halo-carbonyl compounds | CHEMINOVA AS (DK) | 2007-02-28 | — | — | CN | disclosed |
| CN-1871238-A | Triaza-spiropiperidine derivatives for use as GLYT-1 inhibitors in the treatment of neurological and neuropsychiatric disorders | HOFFMANN LA ROCHE (CH) | 2006-11-29 | — | — | CN | disclosed |
| EP-1716088-A1 | CATALYTIC ASYMMETRIC SYNTHESIS OF OPTICALLY ACTIVE ALPHA-HALO-CAR BONYL COMPOUNDS | Cheminova A/S (DK) | 2006-11-02 | — | — | EP | disclosed |
| EP-1678177-A1 | TRIAZA-SPIROPIPERIDINE DERIVATIVES FOR USE AS GLYT-1 INHIBITORS IN THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-12 | — | — | EP | disclosed |
| EP-0772610-B9 | DIHYDROBENZOFURANES | BYK GULDEN LOMBERG CHEM FAB (DE) | 2001-07-25 | — | — | EP | disclosed |
| CN-1068879-C | Dihydrobenzofuranes | BYK GULDEN LOMBERY CHEM FAB GM (DE) | 2001-07-25 | — | — | CN | disclosed |
| EP-0772610-B1 | DIHYDROBENZOFURANES | BYK GULDEN LOMBERG CHEM FAB (DE) | 2000-10-04 | — | — | EP | disclosed |
| US-6121274-A | PHOSPHODIESTERASE INHIBITOR FOR TREATMENT OF RESPIRATORY SYSTEM DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-09-19 | — | — | US | disclosed |
| US-6054475-A | Substituted dihydrobenzofuran-based phosphodiesterase 4 inhibitors useful for treating airway disorders | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-04-25 | — | — | US | disclosed |
| EP-0941221-A1 | SUBSTITUTED DIHYDROBENZOFURANS AS PDE INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1999-09-15 | — | — | EP | disclosed |
| WO-1998022453-A1 | SUBSTITUTED DIHYDROBENZOFURANS AS PDE INHIBITORS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1998-05-28 | — | — | WO | disclosed |
| CN-1159804-A | Dihydrobenzofuranes | BYK GULDEN LOMBERG CHEM FAB (DE) | 1997-09-17 | — | — | CN | disclosed |
| EP-0772610-A1 | DIHYDROBENZOFURANES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003399-A1 | DIHYDROBENZOFURANES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-02-08 | — | — | WO | disclosed |