Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 13/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 5/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 4/20 | 0.34 |
| ▸ | PLA2G5 | P39877 | 4/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.30 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | ACACA | Q13085 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1998620 | 0.76 | GRM2 (0.63) | GRM2 | |
| SCHEMBL6954855 | 0.69 | CYP2D6 (0.56) | CYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL1996376 | 0.68 | GRM2 (0.75) | GRM2 | |
| SCHEMBL8959170 | 0.68 | CYP2D6 (0.52) | PLA2G2ACYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL4820028 | 0.68 | CYP2D6 (0.52) | PLA2G2ACYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL6956902 | 0.68 | CYP2D6 (0.52) | PLA2G2ACYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL16837391 | 0.67 | CYP2D6 (0.51) | PLA2G2ACYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL1639885 | 0.67 | CYP2D6 (0.51) | PLA2G2ACYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL13880484 | 0.67 | CYP2D6 (0.51) | PLA2G2ACYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL6494392 | 0.67 | RAB9A (0.56) | CYP19A1CYP2C9CYP2C19CYP1A2ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1855670-A2 | BENZAZOLE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006091496-A2 | BENZAZOLE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-08-31 | — | — | WO | disclosed |