Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2285648 | 0.82 | PREP (0.48) | PREPPOLBF2ALDH1A1CYP3A4 | |
| SCHEMBL5702805 | 0.82 | PREP (0.48) | PREPPOLBF2ALDH1A1CYP3A4 | |
| SCHEMBL12272394 | 0.79 | PREP (0.66) | PREPKMT2AALDH1A1FKBP1ACYP3A4 | |
| SCHEMBL2228388 | 0.77 | PREP (0.71) | PREPKMT2AALDH1A1FKBP1AACE | |
| SCHEMBL11764594 | 0.77 | PREP (0.71) | PREPKMT2AALDH1A1FKBP1AACE | |
| SCHEMBL28583418 | 0.77 | PREP (0.65) | PREPKMT2AALDH1A1FKBP1ACYP3A4 | |
| SCHEMBL3364774 | 0.77 | PREP (0.49) | PREPKMT2AALDH1A1FKBP1ACYP3A4 | |
| SCHEMBL380893 | 0.77 | PREP (0.57) | PREPKMT2AALDH1A1TSHRNPSR1 | |
| SCHEMBL2082597 | 0.76 | PREP (0.69) | PREPKMT2AALDH1A1FKBP1ACYP3A4 | |
| SCHEMBL22811046 | 0.76 | PREP (0.61) | PREPKMT2AALDH1A1FKBP1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060550-A1 | Methods of determining compounds useful in the treatment of bipolar disorder and methods of treating such disorders | MUDGE ANNE P W | 2007-03-15 | — | — | US | disclosed |
| WO-2006102521-A2 | METHODS OF DETERMINING COMPOUNDS USEFUL IN THE TREATMENT OF BIPOLAR DISORDER AND METHODS OF TREATING SUCH DISORDERS | DAVIS, JOHN M. (US) | 2006-09-28 | — | — | WO | disclosed |