Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.60 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.58 |
| ▸ | CDK9 | P50750 | 2/20 | 0.58 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5524154 | 0.85 | CCNT1 (0.58) | PIK3CAPIK3R1PIK3CDPIK3CBCCNT1 | |
| SCHEMBL10327671 | 0.82 | PIK3CA (0.70) | PIK3CAPIK3R1PIK3CDPIK3CBCCNT1 | |
| SCHEMBL10327676 | 0.78 | PIK3CA (0.67) | PIK3CAPIK3R1PIK3CDPIK3CBCCNT1 | |
| SCHEMBL13555486 | 0.76 | CCNT1 (0.56) | PIK3CAPIK3R1PIK3CDPIK3CBCCNT1 | |
| SCHEMBL10328001 | 0.76 | PIK3CA (0.70) | PIK3CAPIK3R1PIK3CDPIK3CBCCNT1 | |
| SCHEMBL10327594 | 0.75 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL30090947 | 0.75 | PIK3CA (0.71) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL10328002 | 0.74 | PIK3CA (0.72) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL1309279 | 0.74 | PIK3CA (0.61) | PIK3CAPIK3R1PIK3CDPIK3CBCCNT1 | |
| SCHEMBL20920576 | 0.73 | KDM4E (0.63) | PIK3CAPIK3R1PIK3CDPIK3CBCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060582-A1 | 1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases | FINK CYNTHIA A | 2007-03-15 | — | — | US | disclosed |
| EP-1667980-A1 | 1,4-DISUBSTITUTED ISOQUINOLINE DERIVATIVES AS RAF-KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Novartis AG (CH) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005028444-A1 | 1,4-DISUBSTITUTED ISOQUINILONE DERIVATIVES AS RAF-KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060582-A1 | 1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases | BRAF, RAF1, NRAS | PIK3CA 162/4885PIK3R1 250/4885PIK3CD 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.