Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | AGER | Q15109 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | MTOR | P42345 | 5/20 | 0.60 |
| ▸ | CNR2 | P34972 | 1/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.53 |
| ▸ | CDK9 | P50750 | 2/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11927962 | 0.86 | MTOR (0.65) | KDM4EMAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL26985639 | 0.85 | HTR7 (0.56) | KDM4EMAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL31505935 | 0.85 | HTR7 (0.56) | KDM4EMAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL13555486 | 0.80 | CCNT1 (0.56) | KDM4EMAPTTSHRMTORCCNT1 | |
| SCHEMBL23365176 | 0.80 | CYP3A4 (0.70) | KDM4EMAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL29914354 | 0.80 | CYP3A4 (0.70) | KDM4EMAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL27556785 | 0.79 | LMNA (0.53) | KDM4EMAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL16603970 | 0.77 | KDM4E (1.00) | KDM4EMAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL16607164 | 0.77 | KDM4E (0.69) | KDM4EMAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL27649921 | 0.77 | KDM4E (0.66) | KDM4EMAPTLMNAL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10729695-B2 | Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-08-04 | — | — | US | disclosed |
| US-10265320-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2019-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10729695-B2 | Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | AGER, IAPP, GPR119 | KDM4E 3803/4885MAPT 1914/4885LMNA 1219/4885 |
| US-10265320-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | AGER, IAPP, GPR119 | KDM4E 3803/4885MAPT 1914/4885LMNA 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.