Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5520082 | 0.83 | S1PR1 (0.48) | S1PR1 | |
| SCHEMBL25147645 | 0.82 | SIRT1 (0.56) | KMT2AMAPTMEN1L3MBTL1LMNA | |
| SCHEMBL1918133 | 0.81 | KMT2A (0.55) | KMT2AMAPTMEN1L3MBTL1LMNA | |
| SCHEMBL32666145 | 0.81 | KMT2A (0.55) | KMT2AMAPTMEN1L3MBTL1LMNA | |
| SCHEMBL4105569 | 0.80 | KMT2A (0.52) | KMT2AMAPTMEN1L3MBTL1LMNA | |
| SCHEMBL1918737 | 0.79 | KMT2A (0.70) | KMT2AMAPTMEN1LMNAKDM4E | |
| SCHEMBL14584258 | 0.79 | CYP11B1 (0.41) | KMT2ACYP11B1CYP11B2MAPTMEN1 | |
| SCHEMBL14584261 | 0.78 | CYP11B1 (0.40) | KMT2ACYP11B1CYP11B2MAPTMEN1 | |
| SCHEMBL2565349 | 0.78 | KMT2A (0.52) | KMT2AMAPTMEN1L3MBTL1LMNA | |
| SCHEMBL12923709 | 0.78 | KMT2A (0.49) | KMT2AMAPTMEN1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027171-A1 | Cycloalkanepyrrolopyridines as dp receptor antagonists | MERCK FROSST CANADA LTD. (CA) | 2007-02-01 | — | — | US | disclosed |
| US-20070027171-A1 | Cycloalkanepyrrolopyridines as dp receptor antagonists | MERCK FROSST CANADA LTD. (CA) | 2007-02-01 | — | — | US | disclosed |
| US-20070027171-A1 | Cycloalkanepyrrolopyridines as dp receptor antagonists | MERCK FROSST CANADA LTD. (CA) | 2007-02-01 | — | — | US | disclosed |
| EP-1638967-A2 | CYCLOALKANEPYRROLOPYRIDINES AS DP RECEPTOR ANTAGONISTS | Merck Frosst Canada Ltd. (CA) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004111047-A2 | CYCLOALKANEPYRROLOPYRIDINES AS DP RECEPTOR ANTAGONISTS | MERCK FROSST CANADA LTD. (CA) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027171-A1 | Cycloalkanepyrrolopyridines as dp receptor antagonists | PTGIR, PTGDR, PTGDR2 | KMT2A 4654/4885CYP11B1 1897/4885CYP11B2 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.