Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 11/20 | 0.40 |
| ▸ | ACACA | Q13085 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5432646 | 0.89 | CNR1 (0.40) | ACACBACACAKDM4ECKS1BSKP1 | |
| SCHEMBL5636825 | 0.80 | JAK1 (0.40) | CKS1BSKP1SKP2DRD2 | |
| SCHEMBL5636179 | 0.80 | KDM4D (0.33) | KDM4ETDP1 | |
| SCHEMBL5260297 | 0.80 | KDM4D (0.33) | KDM4ETDP1 | |
| SCHEMBL3577407 | 0.79 | KDM4D (0.32) | KDM4ETDP1 | |
| SCHEMBL5506645 | 0.76 | KDM4E (0.41) | ACACBACACAKDM4ECKS1BSKP1 | |
| SCHEMBL633008 | 0.75 | USP30 (0.42) | KDM4EADORA2AADORA2B | |
| SCHEMBL5530317 | 0.72 | KCNH2 (0.47) | ACACBACACACKS1BSKP1SKP2 | |
| SCHEMBL5261192 | 0.71 | KDM4E (0.33) | KDM4ETDP1 | |
| SCHEMBL2369250 | 0.70 | ACACB (0.48) | ACACBACACACKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | disclosed |