Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 7/20 | 0.39 |
| ▸ | ACACA | Q13085 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5432646 | 0.87 | CNR1 (0.40) | KDM4EL3MBTL1CNR1CNR2ACACB | |
| SCHEMBL3584611 | 0.80 | KDM4E (0.36) | KDM4EL3MBTL1ALDH1A1HPGDPOLB | |
| SCHEMBL4039798 | 0.80 | KDM4E (0.36) | KDM4EL3MBTL1ALDH1A1HPGDPOLB | |
| SCHEMBL5530322 | 0.76 | ACACB (0.40) | KDM4ECNR1CNR2ACACBACACA | |
| SCHEMBL5506640 | 0.73 | PLAU (0.40) | CNR1CNR2ACACBACACACKS1B | |
| SCHEMBL5432642 | 0.69 | PLAU (0.41) | CNR1CNR2ACACBACACACKS1B | |
| SCHEMBL13590682 | 0.69 | HPGD (0.64) | ACACBACACAALDH1A1HPGDPOLB | |
| SCHEMBL2369250 | 0.68 | ACACB (0.48) | ACACBACACAHPGDCKS1BSKP1 | |
| SCHEMBL7246825 | 0.67 | BTK (0.61) | L3MBTL1ACACBACACACKS1BSKP1 | |
| SCHEMBL5262829 | 0.67 | BTK (0.61) | L3MBTL1ACACBACACACKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | disclosed |