⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8950260 | 0.72 | BRD4 (0.33) | — | |
| SCHEMBL2514082 | 0.72 | BRD4 (0.33) | — | |
| SCHEMBL8950413 | 0.69 | — | — | |
| SCHEMBL5304972 | 0.67 | — | — | |
| SCHEMBL22779345 | 0.65 | BRD4 (0.39) | — | |
| SCHEMBL19190171 | 0.61 | — | — | |
| SCHEMBL181791 | 0.61 | — | — | |
| SCHEMBL1318400 | 0.61 | — | — | |
| SCHEMBL21611711 | 0.61 | — | — | |
| SCHEMBL16359804 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12083123-B2 | Method for the detection of drug-induced organ or tissue injury in IMPDH inhibitor treated patients | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-09-10 | — | — | US | disclosed |
| US-20220105099-A1 | METHOD FOR THE DETECTION OF DRUG-INDUCED ORGAN OR TISSUE INJURY IN IMPDH INHIBITOR TREATED PATIENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-04-07 | — | — | US | disclosed |
| EP-1765336-A2 | ANGIOGENESIS INHIBITORS | THE JOHNS-HOPKINS UNIVERSITY (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006004795-A2 | ANGIOGENESIS INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2006-01-12 | — | — | WO | disclosed |