Sugi Predict

Sugi Predict / Compounds / SCHEMBL5532013

SCHEMBL5532013

SCHEMBL5532013

C#Cc1ccc(NC(=O)c2cccc(OC)c2N(C=O)c2ccc(C=NN3CCC3)cc2)nc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 4/20 0.38
▸ KMT2A Q03164 4/20 0.38
▸ FGFR4 P22455 2/20 0.37
▸ NPC1 O15118 4/20 0.35
▸ RAB9A P51151 4/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ TP53 P04637 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ RXFP1 Q9HBX9 2/20 0.34
▸ MAPT P10636 2/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ HSD17B10 Q99714 1/20 0.34
▸ F10 P00742 2/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ BRPF1 P55201 3/20 0.33
▸ BRD4 O60885 2/20 0.33
▸ BRD1 O95696 2/20 0.33
▸ PTPN11 Q06124 1/20 0.33
▸ TAF1 P21675 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5530778 0.87 FGFR4 (0.42) MEN1KMT2AFGFR4NPC1RAB9A
SCHEMBL5550016 0.85 NPC1 (0.41) MEN1KMT2ANPC1RAB9ASMN1; SMN2
SCHEMBL5531792 0.85 FGFR4 (0.39) MEN1KMT2AFGFR4NPC1RAB9A
SCHEMBL7132125 0.84 F10 (0.44) MEN1KMT2AFGFR4F10
SCHEMBL5538471 0.84 FGFR4 (0.40) MEN1KMT2AFGFR4NPC1RAB9A
SCHEMBL5532502 0.84 FGFR4 (0.39) MEN1KMT2AFGFR4NPC1RAB9A
SCHEMBL5535284 0.83 FGFR4 (0.39) MEN1KMT2AFGFR4NPC1RAB9A
SCHEMBL5531576 0.81 FGFR4 (0.35) MEN1KMT2AFGFR4NPC1RAB9A
SCHEMBL5534413 0.79 F10 (0.37) MEN1KMT2ANPC1RAB9ARXFP1
SCHEMBL5534115 0.76 NPC1 (0.36) MEN1KMT2AFGFR4NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7312235-B2 Benzamide inhibitors of factor Xa MILLENNIUM PHARMACEUTICALS, INC. (US) 2007-12-25 — — US claimed
EP-1373194-B1 BENZAMIDE INHIBITORS OF FACTOR Xa MILLENNIUM PHARM INC (US) 2007-08-01 — — EP claimed
EP-1373194-A1 BENZAMIDE INHIBITORS OF FACTOR Xa Millennium Pharmaceuticals, Inc. (US) 2004-01-02 — — EP claimed
WO-2002079145-A1 BENZAMIDE INHIBITORS OF FACTOR Xa MILLENNIUM PHARMACEUTICALS, INC. (US) 2002-10-10 — — WO claimed
US-7312235-B2 Benzamide inhibitors of factor Xa MILLENNIUM PHARMACEUTICALS, INC. (US) 2007-12-25 — — US disclosed
EP-1373194-A1 BENZAMIDE INHIBITORS OF FACTOR Xa Millennium Pharmaceuticals, Inc. (US) 2004-01-02 — — EP disclosed
US-20030069250-A1 Benzamide inhibitors of factor Xa MILLENNIUM PHARMACEUTICALS, INC. 2003-04-10 — — US disclosed
WO-2002079145-A1 BENZAMIDE INHIBITORS OF FACTOR Xa MILLENNIUM PHARMACEUTICALS, INC. (US) 2002-10-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030069250-A1 Benzamide inhibitors of factor Xa SERPINC1, TFPI, F12 MEN1 2370/4885KMT2A 2096/4885FGFR4 4054/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.