Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 19/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 17/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 14/20 | 0.50 |
| ▸ | CDK4 | P11802 | 6/20 | 0.50 |
| ▸ | CCND3 | P30281 | 5/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.50 |
| ▸ | AURKA | O14965 | 10/20 | 0.43 |
| ▸ | PLK1 | P53350 | 6/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 3/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4155952 | 0.78 | CDK2 (0.48) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL5522139 | 0.70 | MDM2 (0.33) | — | |
| SCHEMBL13852053 | 0.68 | CDK2 (0.72) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL4147545 | 0.67 | CDK2 (0.50) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL4154687 | 0.67 | CDK2 (1.00) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL4156998 | 0.67 | CDK2 (0.68) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL23849905 | 0.66 | CDK2 (0.60) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL4154799 | 0.66 | L3MBTL1 (0.38) | — | |
| SCHEMBL23849889 | 0.65 | CDK2 (0.58) | CDK2CCNA2CCNA1CDK4CCND3 | |
| SCHEMBL12499779 | 0.64 | CDK2 (0.66) | CDK2CCNA2CCNA1CDK4CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185143-A1 | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185143-A1 | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | MAP3K5, MAP3K9, MAP3K19 | CDK2 52/4885CCNA2 1362/4885CCNA1 1080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.