Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 18/20 | 0.39 |
| ▸ | CDK9 | P50750 | 18/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2989485 | 0.99 | IGF1R (0.41) | IGF1RCCNT1CDK9GSK3BCDK7 | |
| SCHEMBL2986604 | 0.95 | IGF1R (0.44) | IGF1RCCNT1CDK9GSK3BCDK7 | |
| SCHEMBL2995039 | 0.92 | IGF1R (0.42) | IGF1RCCNT1CDK9GSK3BCDK7 | |
| SCHEMBL5532887 | 0.92 | IGF1R (0.43) | IGF1RCCNT1CDK9GSK3BCDK7 | |
| SCHEMBL5535776 | 0.91 | IGF1R (0.41) | IGF1RCCNT1CDK9GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL2985657 | 0.91 | IGF1R (0.42) | IGF1RCCNT1CDK9GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL2984613 | 0.91 | IGF1R (0.41) | IGF1RCCNT1CDK9GSK3BCDK7 | |
| SCHEMBL2993969 | 0.88 | IGF1R (0.39) | IGF1RCCNT1CDK9CASP3CASP7 | |
| Hydrochloric Acid SCHEMBL2990404 | 0.88 | IGF1R (0.40) | IGF1RCCNT1CDK9GSK3BCDK7 | |
| SCHEMBL2987134 | 0.88 | CDK9 (0.39) | IGF1RCCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799691-A1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006037875-A1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2006-04-13 | — | — | WO | disclosed |