Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14679306 | 0.84 | HDAC8 (0.61) | HDAC8HDAC6SMN1; SMN2KCNK3MEN1 | |
| SCHEMBL5539462 | 0.81 | POLB (0.49) | SMN1; SMN2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2382460 | 0.78 | HDAC8 (0.57) | HDAC8HDAC6SMN1; SMN2KCNK3MEN1 | |
| SCHEMBL27668893 | 0.77 | SMN1; SMN2 (0.70) | HDAC8HDAC6SMN1; SMN2KCNK3MEN1 | |
| SCHEMBL28744940 | 0.77 | HDAC8 (0.69) | HDAC8HDAC6SMN1; SMN2KCNK3MEN1 | |
| SCHEMBL21653856 | 0.75 | SMN1; SMN2 (0.79) | HDAC8HDAC6SMN1; SMN2KCNK3MEN1 | |
| SCHEMBL17140602 | 0.75 | SMN1; SMN2 (0.54) | HDAC8HDAC6SMN1; SMN2KCNK3MEN1 | |
| SCHEMBL18971666 | 0.75 | ATM (0.59) | HDAC8HDAC6SMN1; SMN2KCNK3MEN1 | |
| SCHEMBL31540297 | 0.75 | HDAC8 (0.71) | HDAC8HDAC6SMN1; SMN2KCNK3MEN1 | |
| SCHEMBL82080 | 0.75 | HDAC8 (0.71) | HDAC8HDAC6SMN1; SMN2KCNK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178681-B2 | methyl 3-methyl-2-{[2-oxo-1-(2-oxo-ethyl)-1,2,5,6,7,8,9,10-octahydro-cycloocta[b]pyridine-3-carbonyl]-amino}-butyrate; cannabinoid receptor agonist; antiinflammatory agent, immunostimulant, analgesic; atopic dermatitis; excellent in photostability, and have excellent transdermal and oral absorbency | SHIONOGI & CO., LTD. (JP) | 2012-05-15 | — | — | US | disclosed |