SCHEMBL5533980

SCHEMBL5533980

O=C(NCC1CC1)Oc1noc2c1CNCC2

nearest known ligand 0.48

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 14/20 0.48
CHRM5 P08912 9/20 0.46
CHRM1 P11229 9/20 0.46
CHRM2 P08172 8/20 0.46
CHRM4 P08173 8/20 0.46
HTR2C P28335 3/20 0.39
HTR2A P28223 2/20 0.39
HIF1A Q16665 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2582668 0.79 KMT2A (0.42) CHRM3CHRM5CHRM1CHRM2CHRM4
Hydrochloric Acid SCHEMBL2582170 0.78 KMT2A (0.41) CHRM3CHRM5CHRM1CHRM2CHRM4
SCHEMBL5533290 0.73 CHRM3 (0.63) CHRM3CHRM5CHRM1CHRM2CHRM4
SCHEMBL10651354 0.67 CHRM3 (0.97) CHRM3CHRM5CHRM1CHRM2CHRM4
SCHEMBL10654776 0.67 CHRM3 (0.97) CHRM3CHRM5CHRM1CHRM2CHRM4
Hydrochloric Acid SCHEMBL10656906 0.66 CHRM3 (1.00) CHRM3CHRM5CHRM1CHRM2CHRM4
Hydrochloric Acid SCHEMBL10652956 0.66 CHRM3 (1.00) CHRM3CHRM5CHRM1CHRM2CHRM4
SCHEMBL455554 0.65 CHRM3 (0.59) CHRM3CHRM5CHRM1CHRM2CHRM4
SCHEMBL10844384 0.65 CHRM3 (0.97) CHRM3CHRM5CHRM1CHRM2CHRM4
SCHEMBL10843583 0.64 CHRM3 (0.97) CHRM3CHRM5CHRM1CHRM2CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP disclosed
EP-1869053-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-26 EP disclosed
WO-2006105945-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2006-10-12 WO disclosed