Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5534131 | 1.00 | MEN1 (0.62) | MEN1KMT2AGAAPTGDR2ALDH1A1 | |
| SCHEMBL2088275 | 0.91 | PTGDR2 (0.74) | MEN1KMT2AGAAPTGDR2ALDH1A1 | |
| SCHEMBL2088274 | 0.91 | PTGDR2 (0.74) | MEN1KMT2AGAAPTGDR2ALDH1A1 | |
| SCHEMBL2087190 | 0.88 | MEN1 (0.79) | MEN1KMT2AGAAPTGDR2ALDH1A1 | |
| SCHEMBL2087191 | 0.88 | MEN1 (0.79) | MEN1KMT2AGAAPTGDR2ALDH1A1 | |
| SCHEMBL5534134 | 0.85 | PTGDR2 (0.61) | MEN1KMT2AGAAPTGDR2ALDH1A1 | |
| SCHEMBL2087789 | 0.81 | MEN1 (0.78) | MEN1KMT2AGAAPTGDR2ALDH1A1 | |
| SCHEMBL2087786 | 0.81 | MEN1 (0.78) | MEN1KMT2AGAAPTGDR2ALDH1A1 | |
| SCHEMBL2088898 | 0.80 | PTGDR2 (0.72) | MEN1KMT2AGAAPTGDR2ALDH1A1 | |
| SCHEMBL2088896 | 0.80 | PTGDR2 (0.72) | MEN1KMT2AGAAPTGDR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740171-A1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005094816-A1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2005-10-13 | — | — | WO | disclosed |