Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 13/20 | 0.61 |
| ▸ | MEN1 | O00255 | 7/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2088275 | 0.90 | PTGDR2 (0.74) | PTGDR2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2088274 | 0.90 | PTGDR2 (0.74) | PTGDR2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL5534131 | 0.85 | MEN1 (0.62) | PTGDR2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL5534129 | 0.85 | MEN1 (0.62) | PTGDR2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2087193 | 0.84 | PTGDR2 (0.78) | PTGDR2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2088896 | 0.79 | PTGDR2 (0.72) | PTGDR2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2088898 | 0.79 | PTGDR2 (0.72) | PTGDR2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2086396 | 0.77 | PTGDR2 (1.00) | PTGDR2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2086393 | 0.77 | PTGDR2 (1.00) | PTGDR2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2086640 | 0.77 | MEN1 (0.80) | PTGDR2MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740171-A1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005094816-A1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2005-10-13 | — | — | WO | disclosed |