SCHEMBL5534261

SCHEMBL5534261

NC(N)c1cccc(NC(=O)c2ccc(C(=O)O)cc2NC(=O)c2sc3ccccc3c2Cl)c1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRSS12 P56730 16/20 0.72
F10 P00742 4/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15295601 0.89 PRSS12 (0.90) PRSS12F10
SCHEMBL10244025 0.88 PRSS12 (0.82) PRSS12F10
SCHEMBL15283532 0.86 PRSS12 (0.72) PRSS12F10
SCHEMBL2722123 0.84 PRSS12 (0.72) PRSS12F10
SCHEMBL15295703 0.78 PRSS12 (0.71) PRSS12F10
SCHEMBL10244058 0.76 PRSS12 (0.86) PRSS12F10
SCHEMBL15283100 0.76 PRSS12 (1.00) PRSS12F10
SCHEMBL2724093 0.76 F10 (0.64) PRSS12F10
SCHEMBL5539950 0.75 PRSS12 (0.67) PRSS12
SCHEMBL2733894 0.75 PRSS12 (0.85) PRSS12F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012059442-A2 NEUROTRYPSIN INHIBITORS NEUROTUNE AG (CH) 2012-05-10 WO disclosed