Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 10/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4516248 | 0.90 | HRH1 (0.45) | HRH1HTR2AOPRM1HTR1ADRD4 | |
| SCHEMBL4512066 | 0.86 | KCNH2 (0.41) | HRH1HTR2AOPRM1HTR1ADRD4 | |
| SCHEMBL4522763 | 0.85 | KCNH2 (0.46) | HRH1HTR2AOPRM1HTR1ADRD4 | |
| SCHEMBL4134252 | 0.84 | KCNH2 (0.53) | HRH1KCNH2MEN1HRH2HRH3 | |
| SCHEMBL4508044 | 0.82 | KCNH2 (0.41) | KCNH2MEN1MMP2HRH3KCNA5 | |
| SCHEMBL4513184 | 0.82 | MMP2 (0.43) | HRH1HTR2AOPRM1HTR1ADRD4 | |
| SCHEMBL1619406 | 0.81 | KCNH2 (0.47) | HRH1KCNH2MEN1MMP2HRH2 | |
| SCHEMBL5317011 | 0.81 | KCNH2 (0.47) | HRH1KCNH2MEN1HRH2HRH3 | |
| SCHEMBL4516175 | 0.81 | KCNH2 (0.42) | HRH1KCNH2MMP2HRH2HRH3 | |
| SCHEMBL4512049 | 0.80 | KCNH2 (0.48) | HRH1KCNH2MEN1HRH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765831-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123747-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | disclosed |