Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 19/20 | 0.57 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.57 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3854449 | 0.89 | KIF11 (0.60) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3853809 | 0.85 | KIF11 (0.67) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3496301 | 0.81 | KIF11 (0.61) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3496298 | 0.81 | KIF11 (0.61) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3856319 | 0.80 | KIF11 (0.56) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3849586 | 0.79 | KIF11 (0.53) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3496241 | 0.79 | KIF11 (0.63) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3496239 | 0.79 | KIF11 (0.63) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3497750 | 0.79 | KIF11 (0.63) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3497751 | 0.79 | KIF11 (0.63) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765789-A1 | N-(1-(1-BENZYL-4-PHENYL-1H-IMIDAZOL-2-YL)-2,2-DIMETHYLPROPYL)BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS KINESIN SPINDLE PROTEIN (KSP) INHIBITORS FOR THE TREATMENT OF CANCER | Novartis Vaccines and Diagnostics, Inc. (US) | 2007-03-28 | — | — | EP | claimed |
| WO-2006002236-A1 | N- (1- (1-BENZYL -4-PHENYL-1H-IMIDAZOL-2-YL) -2,2-DYMETHYLPROPYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS KINESIN SPINDLE PROTEIN (KSP) INHIBITORS FOR THE TREATMENT OF CANCER | NOVARTIS VACCINES AND DIAGNOSTICS INC. (US) | 2006-01-05 | — | — | WO | claimed |