Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.38 |
| ▸ | PTPN7 | P35236 | 5/20 | 0.37 |
| ▸ | HMGCR | P04035 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL165177 | 0.85 | GRIK1 (0.47) | GRIK1GRIK2PTPN7HMGCRTDP1 | |
| Bicarbonate SCHEMBL15968046 | 0.85 | GRIK1 (0.47) | GRIK1GRIK2PTPN7HMGCRTDP1 | |
| SCHEMBL1897706 | 0.85 | — | — | |
| SCHEMBL38914 | 0.85 | — | — | |
| SCHEMBL38915 | 0.85 | — | — | |
| Bicarbonate SCHEMBL28984116 | 0.84 | HMGCR (0.50) | PTPN7HMGCRTDP1RECQLKDM4E | |
| Bicarbonate SCHEMBL873829 | 0.82 | HMGCR (0.57) | PTPN7HMGCRTDP1RECQLKDM4E | |
| Hydrochloric Acid SCHEMBL16986444 | 0.82 | — | — | |
| SCHEMBL28967870 | 0.82 | GRIK1 (0.33) | GRIK1GRIK2PTPN7HMGCRKDM4E | |
| Bicarbonate SCHEMBL874695 | 0.80 | PTPN7 (0.61) | PTPN7HMGCRTDP1RECQLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105633345-A | Nonaqueous electrolyte solution for secondary battery and nonaqueous electrolyte secondary battery using same | MITSUBISHI CHEM CORP | 2016-06-01 | — | — | CN | disclosed |
| US-20070178379-A1 | Non-aqueous electrolyte secondary battery and non-aqueous electrolyte | SANYO ELECTRIC CO., LTD. (JP) | 2007-08-02 | — | — | US | disclosed |
| EP-1806806-A1 | NON-AQUEOUS ELECTROLYTE SECONDARY BATTERY AND NON-AQUEOUS ELECTROLYTE | Sanyo Electric Co., Ltd. (JP) | 2007-07-11 | — | — | EP | disclosed |