Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5539015 | 1.00 | KCNH2 (0.48) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL5534828 | 0.87 | KCNH2 (0.50) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL5534825 | 0.87 | KCNH2 (0.50) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL3466062 | 0.86 | KCNH2 (0.52) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL5541965 | 0.84 | KCNH2 (0.47) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL5536124 | 0.84 | KCNH2 (0.45) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL5536119 | 0.84 | KCNH2 (0.45) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL5539640 | 0.84 | KCNH2 (0.49) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL5539645 | 0.84 | KCNH2 (0.49) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL5541677 | 0.83 | SIGMAR1 (0.47) | KCNH2CACNA1CSCN5APTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |