Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 3/20 | 0.54 |
| ▸ | ACHE | P22303 | 3/20 | 0.54 |
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | TACR1 | P25103 | 7/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Chloride SCHEMBL5988600 | 0.96 | MEN1 (0.65) | MEN1KMT2APOLBALDH1A1LMNA | |
| SCHEMBL5988603 | 0.87 | MEN1 (0.63) | MEN1KMT2APOLBALDH1A1LMNA | |
| SCHEMBL695065 | 0.84 | MEN1 (0.68) | MEN1KMT2APOLBALDH1A1LMNA | |
| SCHEMBL18143026 | 0.81 | GAA (0.49) | MEN1KMT2APOLBGAABCHE | |
| SCHEMBL27091860 | 0.80 | MEN1 (0.65) | MEN1KMT2APOLBALDH1A1LMNA | |
| SCHEMBL6188507 | 0.80 | MRGPRX1 (0.48) | MEN1KMT2APOLBALDH1A1GAA | |
| SCHEMBL4200062 | 0.79 | MEN1 (0.57) | MEN1KMT2APOLBALDH1A1LMNA | |
| SCHEMBL18143019 | 0.77 | MEN1 (0.53) | MEN1KMT2APOLBALDH1A1BCHE | |
| SCHEMBL8696023 | 0.77 | MEN1 (0.60) | MEN1KMT2APOLBALDH1A1LMNA | |
| SCHEMBL955623 | 0.77 | ACHE (0.62) | MEN1KMT2ABCHEACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1787984-B1 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | ACADIA PHARM INC (US) | 2016-10-19 | — | — | EP | disclosed |
| EP-1787984-A2 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | Arcadia Pharmaceuticals Inc. (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-1263729-B1 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | ACADIA PHARM INC (US) | 2006-12-20 | — | — | EP | disclosed |