Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 4/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5539556 | 1.00 | KCNH2 (0.61) | KCNH2PTGS1SLC6A2SLC6A4CACNA1C | |
| SCHEMBL6010707 | 0.91 | KCNH2 (0.60) | KCNH2PTGS1SLC6A2SLC6A4CACNA1C | |
| SCHEMBL6010825 | 0.85 | KCNH2 (0.68) | KCNH2PTGS1SLC6A2SLC6A4CACNA1C | |
| SCHEMBL6010718 | 0.83 | KCNH2 (0.59) | KCNH2PTGS1SLC6A2SLC6A4CACNA1C | |
| SCHEMBL6010711 | 0.83 | KCNH2 (0.59) | KCNH2PTGS1SLC6A2SLC6A4CACNA1C | |
| SCHEMBL12920573 | 0.83 | KCNH2 (0.75) | KCNH2PTGS1SLC6A2SLC6A4CACNA1C | |
| SCHEMBL5539213 | 0.83 | KCNH2 (0.65) | KCNH2PTGS1SLC6A2SLC6A4CACNA1C | |
| SCHEMBL5541530 | 0.83 | PTGS1 (0.65) | KCNH2PTGS1SLC6A2SLC6A4CACNA1C | |
| SCHEMBL5539219 | 0.83 | KCNH2 (0.65) | KCNH2PTGS1SLC6A2SLC6A4CACNA1C | |
| SCHEMBL5541521 | 0.83 | PTGS1 (0.65) | KCNH2PTGS1SLC6A2SLC6A4CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |