Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.67 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.50 |
| ▸ | NAAA | Q02083 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6359399 | 0.90 | SMN1; SMN2 (0.72) | NAMPTHDAC3MCHR1GAASMN1; SMN2 | |
| SCHEMBL19133524 | 0.90 | NAMPT (0.61) | NAMPTHDAC3MCHR1GAASMN1; SMN2 | |
| SCHEMBL17623594 | 0.90 | HDAC3 (0.63) | NAMPTHDAC3MCHR1GAASMN1; SMN2 | |
| SCHEMBL14449903 | 0.86 | NAMPT (0.58) | NAMPTHDAC3MCHR1GAASMN1; SMN2 | |
| SCHEMBL12988864 | 0.86 | L3MBTL1 (0.63) | NAMPTHDAC3MCHR1GAASMN1; SMN2 | |
| SCHEMBL3900808 | 0.86 | MCHR1 (0.60) | NAMPTHDAC3MCHR1GAASMN1; SMN2 | |
| SCHEMBL7556161 | 0.86 | NAMPT (0.58) | NAMPTHDAC3MCHR1GAASMN1; SMN2 | |
| SCHEMBL3697123 | 0.85 | NAMPT (1.00) | NAMPT | |
| SCHEMBL5628377 | 0.85 | NAMPT (0.56) | NAMPTHDAC3MCHR1GAAGSK3B | |
| SCHEMBL21610884 | 0.84 | NAMPT (0.56) | NAMPTHDAC3MCHR1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262223-B2 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-08-28 | — | — | US | disclosed |
| US-7262223-B2 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-08-28 | — | — | US | disclosed |
| EP-1715857-A1 | AMIDINE DERIVATIVES FOR TREATING AMYLOIDOSIS | Neurochem (International) Limited (CH) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005079780-A1 | AMIDINE DERIVATIVES FOR TREATING AMYLOIDOSIS | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2005-09-01 | — | — | WO | disclosed |
| US-20050182118-A1 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182118-A1 | Amidine derivatives for treating amyloidosis | APP, IAPP, GRN | NAMPT 131/4885HDAC3 3707/4885MCHR1 3953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.