Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 15/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5540764 | 0.91 | GRIN2B (0.56) | GRIN2BSIGMAR1GRIN1DRD4SLC6A2 | |
| SCHEMBL4202104 | 0.84 | GRIN2B (0.68) | GRIN2BSIGMAR1GRIN1DRD4SLC6A2 | |
| SCHEMBL955623 | 0.82 | ACHE (0.62) | GRIN2BDRD4OPRM1OPRL1 | |
| SCHEMBL5275183 | 0.79 | SLC6A2 (0.69) | GRIN2BSIGMAR1GRIN1SLC6A2SLC6A4 | |
| SCHEMBL7693701 | 0.79 | ACHE (0.68) | GRIN2BSIGMAR1GRIN1SLC6A2SLC6A4 | |
| SCHEMBL5273114 | 0.79 | SLC6A2 (0.69) | GRIN2BSIGMAR1GRIN1DRD4SLC6A2 | |
| SCHEMBL14093072 | 0.79 | GRIN2B (0.61) | GRIN2BSIGMAR1GRIN1OPRM1OPRL1 | |
| SCHEMBL5272251 | 0.78 | SLC6A2 (0.67) | GRIN2BSIGMAR1GRIN1DRD4SLC6A2 | |
| SCHEMBL5266734 | 0.78 | SLC6A2 (0.57) | GRIN2BSIGMAR1GRIN1SLC6A2SLC6A4 | |
| SCHEMBL11999863 | 0.78 | DRD4 (0.64) | GRIN2BSIGMAR1GRIN1DRD4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1787984-B1 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | ACADIA PHARM INC (US) | 2016-10-19 | — | — | EP | disclosed |
| EP-1787984-A2 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | Arcadia Pharmaceuticals Inc. (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-1263729-B1 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | ACADIA PHARM INC (US) | 2006-12-20 | — | — | EP | disclosed |