Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2509857 | 0.83 | PDE5A (0.60) | PDE5A | |
| SCHEMBL2502972 | 0.83 | PDE5A (0.60) | PDE5A | |
| Hydrochloric Acid SCHEMBL6407788 | 0.82 | PDE5A (0.59) | PDE5A | |
| Hydrochloric Acid SCHEMBL5537994 | 0.82 | PDE5A (0.59) | PDE5A | |
| SCHEMBL14599794 | 0.74 | PDE5A (0.60) | PDE5A | |
| SCHEMBL5532312 | 0.72 | HTR7 (0.61) | PDE5A | |
| SCHEMBL14599797 | 0.72 | HTR7 (0.61) | PDE5A | |
| SCHEMBL2504528 | 0.72 | HTR7 (0.61) | PDE5A | |
| SCHEMBL5528826 | 0.72 | HTR7 (0.61) | PDE5A | |
| SCHEMBL14599799 | 0.71 | PDE5A (0.72) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851227-A1 | AN EFFICIENT AND STEREOSELECTIVE PROCESS FOR LARGE SCALE SYNTHESIS OF 3-(R)-3- (2,3-DIHYDROBENZOFURAN-5-YL)-1,2,3,4- TETRAHYDROPYRROLO{3,4-B}QUINOLIN-9-ONE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006093719-A1 | AN EFFICIENT AND STEREOSELECTIVE PROCESS FOR LARGE SCALE SYNTHESIS OF 3-(R)-3- (2,3-DIHYDROBENZOFURAN-5-YL)-1,2,3,4- TETRAHYDROPYRROLO{3,4-B}QUINOLIN-9-ONE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-09-08 | — | — | WO | disclosed |