Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.60 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.60 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.60 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.45 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59553 | 1.00 | — | — | |
| SCHEMBL1470378 | 1.00 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Ammonia Solution, Strong SCHEMBL31658236 | 0.97 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Hydrochloric Acid SCHEMBL8905629 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL28810492 | 0.97 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| SCHEMBL28814473 | 0.97 | — | — | |
| SCHEMBL31585729 | 0.97 | — | — | |
| Ammonia Solution, Strong SCHEMBL30389928 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL29528206 | 0.97 | — | — | |
| SCHEMBL27978834 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102781926-B | Method for producing gamma-butyrolactone | 梅塔玻利克斯公司 | 2016-11-09 | — | — | CN | claimed |
| CN-102781926-B | Method for producing gamma-butyrolactone | 梅塔玻利克斯公司 | 2016-11-09 | — | — | CN | disclosed |
| WO-2012177601-A2 | MICROORGANISMS FOR PRODUCING ISOBUTANOL AND METHODS RELATED THERETO | GENOMATICA, INC. (US) | 2012-12-27 | — | — | WO | disclosed |
| EP-1778894-A2 | MICROFLUID DEVICE AND SYNTHETIC METHODS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2005118915-A2 | MICROFLUID DEVICE AND SYNTHETIC METHODS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2005-12-15 | — | — | WO | disclosed |