SCHEMBL5541353

SCHEMBL5541353

[CH2]CCc1ccc(Oc2ccccc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 4/20 0.58
LTA4H P09960 6/20 0.57
TSHR P16473 1/20 0.52
SRD5A2 P31213 3/20 0.50
FFAR4 Q5NUL3 3/20 0.49
EPHX2 P34913 1/20 0.49
NR1H2 P55055 1/20 0.46
BAX Q07812 1/20 0.46
MAOA P21397 1/20 0.46
MMP12 P39900 1/20 0.45
MMP13 P45452 1/20 0.45
PLAAT3 P53816 1/20 0.45
PLAAT5 Q96KN8 1/20 0.45
PLAAT2 Q9NWW9 1/20 0.45
PLAAT4 Q9UL19 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5534679 0.88 FFAR1 (0.55) FFAR1LTA4HTSHRSRD5A2FFAR4
SCHEMBL19322270 0.86 LTA4H (0.67) FFAR1LTA4HTSHRSRD5A2FFAR4
SCHEMBL5535812 0.86 FFAR1 (0.53) FFAR1LTA4HTSHRSRD5A2FFAR4
SCHEMBL5539299 0.84 FFAR1 (0.51) FFAR1LTA4HTSHRSRD5A2FFAR4
SCHEMBL28724005 0.84 FFAR1 (0.64) FFAR1LTA4HTSHRSRD5A2FFAR4
SCHEMBL28297211 0.82 LTA4H (0.61) FFAR1LTA4HTSHRSRD5A2NR1H2
SCHEMBL2201304 0.82 FFAR1 (0.62) FFAR1LTA4HTSHRSRD5A2FFAR4
SCHEMBL694932 0.82 LTA4H (0.61) FFAR1LTA4HTSHRSRD5A2NR1H2
SCHEMBL19322272 0.82 FFAR1 (0.62) FFAR1LTA4HTSHRSRD5A2FFAR4
SCHEMBL5540055 0.82 FFAR1 (0.50) FFAR1LTA4HTSHRFFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0960108-B1 MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2004-10-27 EP claimed
US-6329400-B1 INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS GLAXO WELLCOME INC. 2001-12-11 US claimed
US-6194451-B1 PREVENT RELEASE TUMOR NECROSIS FACTOR; ANTIINFLAMMATORY AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2001-02-27 US claimed
US-6172064-B1 METALLOPROTEASE INHIBITOR; ANTIARTHRITIC AGENTS, ANTIDIABETIC AGENTS; ANTITUMOR AGENTS GLAXO WELLCOME INC. 2001-01-09 US claimed
WO-2000012082-A1 FORMAMIDE COMPOUNDS AS THERAPEUTIC AGENTS GLAXO GROUP LIMITED (GB) 2000-03-09 WO claimed
EP-0960108-A1 MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN S.p.A. (IT) 1999-12-01 EP claimed
WO-1998033788-A1 MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN S.P.A. (IT) 1998-08-06 WO claimed
US-12030970-B2 Curable composition and stereolithographic resin composition comprising same KURARAY CO., LTD. (JP) 2024-07-09 US disclosed
US-11981763-B2 Resin composition for stereolithographic modeling KURARAY NORITAKE DENTAL INC. (JP) 2024-05-14 US disclosed
EP-3900693-B1 USE OF A RESIN COMPOSITION KURARAY NORITAKE DENTAL INC (JP) 2024-03-20 EP disclosed
US-11814454-B2 Curable composition, and resin composition for stereolithography prepared therefrom KURARAY CO., LTD. (JP) 2023-11-14 US disclosed
EP-4268792-A1 ADHESIVE COMPOSITION FOR PHOTOFABRICATION ARTICLES Kuraray Noritake Dental Inc. (JP) 2023-11-01 EP disclosed
WO-2023182514-A1 ADHESIVE COMPOSITION FOR STEREOLITHOGRAPHIC ARTICLE AND NON-STEREOLITHOGRAPHIC ARTICLE クラレノリタケデンタル株式会社 2023-09-28 WO disclosed
CN-1043886-C Substituted pyrimidines, their production and use as pesticides and fungicides HOECHST AG (DE) 1999-06-30 CN disclosed
EP-0922050-A1 3-DESCLADINOSE-2,3-ANHYDROERYTHROMYCIN DERIVATIVES ABBOTT LABORATORIES (US) 1999-06-16 EP disclosed
WO-1998033788-A1 MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN S.P.A. (IT) 1998-08-06 WO disclosed
US-5750510-A ANTIBIOTICS ABBOTT LABORATORIES (US) 1998-05-12 US disclosed
WO-1997042205-A1 3-DESCLADINOSE-2,3-ANHYDROERYTHROMYCIN DERIVATIVES ABBOTT LABORATORIES (US) 1997-11-13 WO disclosed
CN-1076692-A Substituted pyrimidines, their production and use as pesticides and fungicides HOECHST AG (DE) 1993-09-29 CN disclosed
EP-0485026-A2 Antimanic phenoxymethylene bisphosphonate derivatives MERCK SHARP & DOHME LTD. (GB) 1992-05-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11814454-B2 Curable composition, and resin composition for stereolithography prepared therefrom WASF2, COPE, ARCN1 FFAR1 493/4885LTA4H 1081/4885TSHR 4743/4885
US-12030970-B2 Curable composition and stereolithographic resin composition comprising same ARL1, ASH2L, VCL FFAR1 1616/4885LTA4H 640/4885TSHR 4710/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.