Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.36 |
| ▸ | BCL2 | P10415 | 5/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL554340 | 1.00 | TP53 (0.39) | TP53USP2ENPP2POLBCNR1 | |
| SCHEMBL553495 | 0.90 | BCL2 (0.41) | TP53USP2ENPP2POLBBCL2 | |
| SCHEMBL553496 | 0.90 | BCL2 (0.41) | TP53USP2ENPP2POLBBCL2 | |
| SCHEMBL26647739 | 0.86 | MEN1 (0.35) | TP53USP2ENPP2CNR1CNR2 | |
| SCHEMBL31451035 | 0.86 | MEN1 (0.35) | TP53USP2ENPP2CNR1CNR2 | |
| SCHEMBL10175204 | 0.81 | POLB (0.41) | TP53USP2POLBBCL2BCL2L1 | |
| SCHEMBL26648243 | 0.80 | CNR1 (0.35) | TP53CNR1CNR2BCL2BCL2L1 | |
| SCHEMBL26648402 | 0.78 | TP53 (0.32) | TP53USP2POLBBCL2BCL2L1 | |
| SCHEMBL26647936 | 0.77 | MAPT (0.39) | TP53USP2MAPT | |
| SCHEMBL26648660 | 0.77 | MAPT (0.39) | TP53USP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9248140-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2016-02-02 | — | — | US | disclosed |
| US-9018381-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2015-04-28 | — | — | US | disclosed |
| EP-2601177-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | AstraZeneca AB (SE) | 2013-06-12 | — | — | EP | disclosed |
| US-20120035134-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | US | disclosed |
| WO-2012017251-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035134-A1 | CHEMICAL COMPOUNDS | BCL2, BCL2L1, BAX | TP53 23/4885USP2 2802/4885ENPP2 543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.