SCHEMBL5543501

SCHEMBL5543501

[CH]=CCN(CC)CC

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2977598 0.72 KCNH2 (0.35)
SCHEMBL2977599 0.72 KCNH2 (0.35)
SCHEMBL386205 0.72
SCHEMBL294278 0.69
Bromide SCHEMBL8751675 0.69 KCNH2 (0.34)
SCHEMBL7542444 0.69
SCHEMBL25169856 0.67
SCHEMBL65290 0.67
SCHEMBL1807349 0.67
SCHEMBL11575083 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2917197-B1 TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME ZAFGEN INC (US) 2019-06-05 EP claimed
US-20180002307-A1 PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME ZAFGEN, INC. 2018-01-04 US claimed
EP-2486004-B1 SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY ZAFGEN INC (US) 2017-05-03 EP claimed
US-9561230-B2 Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators ZAFGEN, INC. (US) 2017-02-07 US claimed
EP-2705035-B1 TRICYCLIC PYRAZOLE SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME ZAFGEN INC (US) 2016-12-14 EP claimed
US-20160324865-A1 TRICYCLIC PYRAZOLE SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME ZAFGEN, INC. 2016-11-10 US claimed
US-20160256469-A1 TRICYCLIC SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME ZAFGEN, INC. 2016-09-08 US claimed
EP-2705030-B1 PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME ZAFGEN INC (US) 2016-07-27 EP claimed
US-9290472-B2 Partially saturated tricyclic compounds and methods of making and using same ZAFGEN, INC. (US) 2016-03-22 US claimed
US-9242997-B2 Tricyclic pyrazole sulphonamide compunds and methods of making and using same ZAFGEN, INC. (US) 2016-01-26 US claimed
US-9067905-B2 Sulphone compounds and methods of making and using same ZAFGEN, INC. (US) 2015-06-30 US claimed
WO-2014071363-A1 TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME ZAFGEN, INC. (US) 2014-05-08 WO claimed
US-20140088078-A1 Partially Saturated Tricyclic Compounds and Methods of Making and Using Same ZAFGEN, INC. (US) 2014-03-27 US claimed
US-20140080822-A1 Tricyclic Pyrazole Sulphonamide Compounds and Methods of Making and Using Same ZAFGEN, INC. (US) 2014-03-20 US claimed
US-20140073623-A1 Tricyclic Sulfonamide Compounds and Methods of Making and Using Same ZAFGEN, INC. (US) 2014-03-13 US claimed
EP-2705036-A1 TRICYCLIC SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME ZAFGEN INC. (US) 2014-03-12 EP claimed
EP-2705035-A1 TRICYCLIC PYRAZOLE SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME Zafgen, Inc. (US) 2014-03-12 EP claimed
US-20130053364-A1 Sulphone Compounds and Methods of Making and Using Same ZAFGEN, INC. 2013-02-28 US claimed
WO-2012154679-A1 TRICYCLIC PYRAZOLE SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME ZAFGEN CORPORATION (US) 2012-11-15 WO claimed
WO-2012154678-A1 TRICYCLIC SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME ZAFGEN CORPORATION (US) 2012-11-15 WO claimed