Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.39 |
| ▸ | PDE8B | O95263 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5548632 | 0.73 | KDM1A (0.40) | KDM1AHRH2 | |
| SCHEMBL5550007 | 0.72 | KAT2B (0.39) | — | |
| SCHEMBL15055509 | 0.71 | STK17B (0.50) | PRMT5KDM1APDE7BPDE8BTRPV1 | |
| SCHEMBL16336181 | 0.71 | STK17B (0.50) | PRMT5KDM1APDE7BPDE8BTRPV1 | |
| SCHEMBL16336972 | 0.71 | STK17B (0.50) | PRMT5KDM1APDE7BPDE8BTRPV1 | |
| SCHEMBL15056902 | 0.68 | STK17B (0.51) | PRMT5KDM1APDE7BTRPV1FPR3 | |
| SCHEMBL16336962 | 0.68 | STK17B (0.51) | PRMT5KDM1APDE7BTRPV1FPR3 | |
| SCHEMBL16337923 | 0.68 | STK17B (0.51) | PRMT5KDM1APDE7BTRPV1FPR3 | |
| SCHEMBL5337684 | 0.68 | PRMT5 (0.53) | PRMT5KDM1APDE7BMETTL3PDE8B | |
| SCHEMBL19141219 | 0.68 | PRMT5 (0.53) | PRMT5KDM1APDE7BMETTL3PDE8B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |