Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 4/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ILK | Q13418 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5548887 | 0.99 | KAT2B (0.40) | KAT2BIKBKBCHUKMEN1KMT2A | |
| SCHEMBL5549838 | 0.93 | PGK1 (0.40) | KAT2BKMT5ATLR7GSK3AGSK3B | |
| SCHEMBL5549410 | 0.90 | TLR9 (0.43) | MEN1KMT2AAPAF1NSD2HTT | |
| SCHEMBL5549394 | 0.87 | PGK1 (0.39) | KAT2BKMT5ATLR9TLR7GSK3A | |
| SCHEMBL3526664 | 0.84 | GAA (0.45) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL5545590 | 0.82 | GSK3B (0.35) | GSK3AGSK3B | |
| SCHEMBL3521775 | 0.82 | GSK3B (0.36) | IKBKBCHUKGSK3AGSK3B | |
| SCHEMBL3529268 | 0.82 | ADORA1 (0.37) | GSK3AGSK3B | |
| SCHEMBL5548632 | 0.81 | KDM1A (0.40) | KAT2BMEN1KMT2ANPC1RAB9A | |
| SCHEMBL5543598 | 0.81 | HSD17B10 (0.43) | KAT2BGSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |